The p53 inducing drug dosage may determine quiescence or senescence
نویسندگان
چکیده
منابع مشابه
The p53 inducing drug dosage may determine quiescence or senescence
protein p53 regulates the fate of cells [1]. Blagosklonny and his colleagues [2], and others [3] in a series of studies have been using the non-genotoxic p53 activator, Nutlin-3a, to understand further how p53 induction can determine whether cells arrest die or senesce. In earlier work the p53 dependence of cell cycle arrest, apoptosis, autophagy and senescence has been unequivocally demonstrat...
متن کاملP53 levels govern the choice between senescence and quiescence
Activation of p53 plays a pivotal role in protecting against the survival and systemic spread of potential tumour cells. It can also influence the aging process and, reciprocally, p53 function has been reported to decline with age [1,2]. The biological outcome of inducing p53 is of great topical interest, with much focus on the numerous factors that lead to growth arrest or programmed cell deat...
متن کاملmTOR favors senescence over quiescence in p53-arrested cells
p53 tumor suppressor protein controls cell fate by inducing apoptosis or cell cycle arrest in response to cell stress [1]. Cell cycle arrest can be temporary (quiescent) or permanent (senescent) depending on p53 regulation [2,3]. Under normal conditions, p53 binds to MDM2, which transports the protein to the cytoplasm where it undergoes rapid proteosomal degradation. A class of chemotherapeutic...
متن کاملThe choice between p53-induced senescence and quiescence is determined in part by the mTOR pathway
Transient induction of p53 can cause reversible quiescence and irreversible senescence. Using nutlin-3a (a small molecule that activates p53 without causing DNA damage), we have previously identified cell lines in which nutlin-3a caused quiescence. Importantly, nutlin-3a caused quiescence by actively suppressing the senescence program (while still causing cell cycle arrest). Noteworthy, in thes...
متن کاملAnother "Janus paradox" of p53: induction of cell senescence versus quiescence
other protein shows such multiplicity and diversity of functions as the tumor suppressor p53 [1,2]. Initially, the role of p53 as " the guardian of the cellular genome " was considered to be providing protection from progression to malignancy. This was mediated by its function as a transcription factor of the genes controlling cell cycle and apoptosis [3]. Subsequent studies have identified a l...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Aging
سال: 2010
ISSN: 1945-4589
DOI: 10.18632/aging.100229